Molecular Formula | C38H64N2O21 |
Molar Mass | 884.92 |
Density | 1.27±0.1 g/cm3(Predicted) |
Boling Point | 833.0±75.0 °C(Predicted) |
Storage Condition | 2-8°C,干燥,密封 |
MDL | MFCD21363287 |
In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
biological activity | Bis-PEG13-NHS ester is a PROTAC Bridge belonging to the PEG class and the Alkyl/ether class. Bis-PEG13-NHS ester can be used to synthesize a range of PROTAC molecules. Bis-PEG13-NHS ester is a cleavable ADC attachment Bridge used in the synthesis of antibody drug conjugates (ADCs). |